The main American Football season runs from mid-to-late August through to late January and, therefore, with around five months of action the matches and the outright betting are all covered by the leading bookmakers from around the world.

In the US the main forms are played as high school football, college football or professional American football. Plenty of bookmakers will have betting odds on college football (NCAA), but it's the professional game (NFL) that attracts the most betting markets and activity from punters and the bookmakers.

Known in the United States as 'football' the sport is contested between two teams of eleven players with the objective of the game being to advance the ball into the opposing team’s end zone. The ball is advanced down the pitch by either players running of throwing the ball to another teammate, while the team in possession of the ball has just 4 attempts (plays or downs) to gain a certain amount of yards - failure to do so results in losing possession of the ball.

Points are scored once a team gets into the opposing sides end zone with the ball and in doing so score 6 points. That same team can then add an extra point by kicking a field goal through the posts. Points can also be scored by teams opting to kick a field goal for 3 points when they feel they are close enough to the posts, while a safety, scored when the opposing team when the side in possession at the end of a down is responsible for the ball becoming dead behind its own goal line, gets that team 2 points.

The NFL is made up of 34 sides across the whole of America, with each team split into regional divisions, AFC East, AFC North, AFC South, AFC West, NFC East, NFC North, NFC South and NFC West, with the winners from each divisions playing each other in a knockout format until the two remaining side meet in the Super Bowl – the biggest and most famous game in the sport.